Q134] A 55 year-old woman comes to your office complaining of sweating, headache, nausea and vomiting. This happened shortly after her lunch. She had some grape fruit juice and redwine with her lunch. She had She has a long history of depression but she does not believe in conventional antidepressants. She is not being medically treated for depression and anxiety however, she has been using over the counter herbal medicine for her depression. Which of the following is the most likely medication she has been using ?
a] Ginkgo biloba
b] Kava – Kava
c] St.johns wort
d] Ephedra
e] Yohimbine
good one
ephedra?
c- 100%
E, Yohimbe ,not Yohimbine (this is used to reverse xyalzine)
Yohimbe–Yohimbe blocks monoamine oxidase (MAO), dopamine and serotonin. Blocking MAO can help with depression. here combine with “RED WINE” then……
c, grapefruit juice inhibit cyp350 and reacts with st john’s wort
c
this question is genius . hahaha
Yohimbine and st john’s wort can cause the same effect
red wine and P450 inhibitor via grapefruit juice .
But the twist that St john’s wort is most commonly used as herbal anti depression compared to yohimbine( most commonly used to tx male impotence)
So i guess the answer should be st john’s wort . hahah
Dr.Red please explain