Question of the Week # 125

Q125) A 55 Year old man comes to your office with complaints of progressively shortness of breath on exertion for the past 3 months. Physical examination reveals scattered wheezes . Pulmonary function tests reveal irreversible obstructive pattern. The patient is started on tiotropium inhaler. His other medications include enalapril for hypertension and over-the-counter vitamin supplements that he routinely uses on a daily basis which include Vitamin A, Vitamin B-complex, Beta-carotene , Selenium and Vitamin E. Chest X-ray is consistent with chronic obstructive airway disease but did not reveal any lung nodules or masses. The patient is counselled about lung cancer risk and strongly counselled on cessation of smoking. In addition to counselling regarding smoking cessation, which of the following is the most important measure to reduce his lung cancer risk?

A) CT scan of the chest every year

B) Discontinue Vitamin E

C) Discontinue Selenium

D) Discontinue Beta Carotene

E) Start Vitamin D supplements for chemoprevention

6 Responses


    The collective results of the ATBC trial and CARET “provide strong evidence of the adverse effect of beta-carotene supplement use on lung cancer incidence in smokers,” write Anna J. Duffield-Lillico and Colin B. Begg of Memorial Sloan-Kettering Cancer Center in New York in an accompanying editorial

  2. if a person is smoker vit A increase the risk of lung cancer
    this patient will stop smoking and there is no increased risk

  3. D. See study by Omann et al in NEJM 1996.

  4. E
    Prospective trial 2013 – vitamin D lowers risk of lung cancer.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: