435) A 29 year old woman is seen in your office for fatigue and exertional shortness of breath of 2 week duration. Past medical history is significant for hospitalization for splenic vein thrombosis 1 year ago. She received heparin 1 year ago and therafter, coumadin for 6 months. She is off anticoagulation now. Physical examination is unremarkable. Laboratory Studies reveal
WBC 2400/µl
HGB: 6.8 gm%
MCV 84 fl
Platelets : 80k/µl
Reticulocyte count 4.5%
Haptoglobin : Undetectable
Lactic Dehydrogenase (LDH) 800U/L
Direct Coombs Test : Negative
Which of the following is the best step in diagnosing this condition?
A) Hemoglobin Electrophoresis
B) Flow cytometry
C) Osmotic Fragility Test
D) Urine Hemosiderin
E) Heparin Antibody Testing
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