Question of the Week # 170

170) A 41 year old woman is evaluated in the office for 20lb weight loss over the last three months. She has a history of Hodgkin’s disease involving mediastinal and cervical lymph nodes and was treated with chemotherapy and Involved field radiation therapy at the age of 12.  She is born in the USA and never traveled outside United States. Her recent tuberculin skin test was 2mm about 1 month ago. Recent mammogram was normal. She denies any night sweats or pruritus. She reports chronic cough over the last 6 months associated with intermittent mild hemoptysis. On physical examination, there is no peripheral lymphadenopathy. A Chest X-ray is shown below:

 

 

 

 

 

 

Which of the following is the most likely explanation for the patient’s abnormalities?

A)     Tuberculosis

B)      Long term sequel of Hodgkin’s therapy

C)      Recurrent Hodgkin’s disease

D)     Radiation fibrosis

E)      Radiation Pneumonitis

7 Responses

  1. D

  2. cc

  3. b…..radiation increases the risk of solid tumors such as breast and lung cancer.
    hx of weight loss and cough indicates lung cancer

  4. c

  5. B…look like lung fibrosis, but I can not said lung cancer is there

  6. B:

  7. Patients treated with chemotherapy and/or radiotherapy for Hodgkin lymphoma (HL) have risk of developed:
    Leukemia ,Non-Hodgkin lymphoma,Solid tumors (lung, breast, bone, stomach, colon, thyroid, melanoma).

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