Question of the Week # 329

329) A 62 year old man presents to your office complaining of dry cough for past several months. Recently, he also noticed shortness of breath on exertion. He denies any fever, hemoptysis or weight loss. He has no history of infections. He does not smoke. He worked as a soft-ware consultant for past 40 years. He has no other medical problems and has never been hospitalized.  On examination, he is afebrile, blood pressure 120/80 mm Hg, RR 18/min and Pulse 82/min. There are no palpable chest-wall masses or lymphadenopathy. On auscultation, fine crackles are heard at bilateral lung bases. A high resolution CT scan of the lungs shows sub-pleural cyst formation with honey combing. The patient undergoes an open lung biopsy for confirmation of diagnosis. Which of the following histo-pathological patterns is likely to be found in this condition?

A) Non-specific Interstitial Pneumonia ( NSIP)

B) Desquamative Interstitial Pneumonia (DIP)

C) Usual Interstitial Pneumonia (UIP)

D) Bronchiolitis Obliterans Organizing Pneumonia (BOOP)

E) Acute Interstitial Pneumonia (AIP)

11 Responses

  1. C) Usual Interstitial Pneumonia (UIP)

  2. D is the answer

  3. ddddddddddd

  4. b

  5. A: non-specific interstitial pneumonia

  6. d

  7. D

  8. Sounds like boop to me

  9. ccc

  10. C
    Usual interstitial pneumonia (UIP) is a form of lung disease characterized by progressive scarring of both lungs.[1] The scarring (fibrosis) involves the supporting framework (interstitium) of the lung. UIP is thus classified as a form of interstitial lung disease. The term “usual” refers to the fact that UIP is the most common form of interstitial fibrosis. “Pneumonia” indicates “lung abnormality”, which includes fibrosis and inflammation. The term used for UIP in the British literature is cryptogenic fibrosing alveolitis, a term that has fallen out of favor since the basic underlying pathology is now thought to be fibrosis, not inflammation.

  11. C

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